Unbiased Reviews
Real research
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Unbiased reviews
Real research
Here, we’ll post all our upcoming research trials. Where you’ll be able to find out what they’re about and how to sign-up.
So check back regularly for updates, or subscribe now and never miss the chance to make a change.
*We run much of our cutting edge research from The Functional Gut Clinic.
IBS affects many people in the UK and around the world. And it can have a big impact on quality of life. The causes are complex, but gut bacteria imbalances and changes to gut permeability (aka “leaky gut”) seem to be significant factors. This study investigates the effect of a food supplement (containing two natural compounds) on gut barrier function, to assess whether they could help to treat a leaky gut people with IBS-D.
Uncontrolled bowel movements are more common than you think, with up to 1 in 4 women experiencing faecal incontinence at some point. And this can have a huge impact on your quality of life.
Three food supplements (vitamin D, green tea and curcumin) have been linked with reduced symptoms individually. But they’ve never been tested together in a combined supplement…until now.
These studies will aim to revolutionise the treatment for Irritable Bowel Syndrome with Diarrhoea (IBS-D). Register your interest now to be the first to hear.
Transforming ibs-c treatment with intestinal microbiota transplantation
This study aims to revolutionise the treatment for Irritable Bowel Syndrome with Constipation (IBS-C). We’re investigating the safety, efficacy and impact of a novel intestinal microbiota product. This randomized, placebo-controlled trial will involve participants with IBS-C, living in the UK. Participants will attend 6 in-person clinic visits, taking capsules on specific days and completing basic tests to assess its effects on IBS-C symptoms and the gut microbiome. Join us in reshaping the future of IBS treatment and be part of this pioneering study.
Investigating the effects of probiotics in the microbiome of healthy people
Probiotic supplements contain live bacteria and/or yeast but previous studies have shown that probiotic supplements do not change the gut microbiome in healthy adults. We gave 41 healthy adults a multi-strain probiotic for 8 weeks and looked at the gut microbiome before and after. Whilst probiotic supplementation did not change the overall diversity of the gut microbiome in our healthy adults, some changes in functional pathways of the gut microbiome were seen. Whether these functional changes are beneficial needs to be elucidated in future studies.
Investigating the use of alginates (Gaviscon) during previnvestigation PPI wash-out and their impact on compliance and symptoms
People need to stop proton pump inhibitors (PPIs), such as omeprazole and lansoprazole, for one week before reflux testing. However, this can lead to troublesome symptoms including heartburn. We randomized people to take a regimen of Gaviscon liquid four times per day (once after every meal and once before bed) or to use Gaviscon as and when required. The people taking the structured regimen of Gaviscon experienced less symptoms. Future studies can look to see if this can help people to come off PPI medications.
Investigating enzyme-rich malt extract (ERME™) for the treatment of chronic constipation
Fibre is recommended in people with constipation but increasing fibre can lead to other symptoms such as bloating and abdominal discomfort. Enzyme-rich malt extract (ERME) is a food supplement made from barley grain. We gave 20 people with constipation ERME (around one tablespoon with food for four weeks). Taking ERME appeared to help constipation and reduce daily symptoms of abdominal pain and bloating. This study was open-label and so future randomized, controlled studies are required.
Want us to put your product to the test? Our team at the Functional Gut Clinic are the accredited experts in running clinical and lifestyle trials. So if you’re interested in getting your product to the gold standard, get in touch today.
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